Publications

@article{https://doi.org/10.2903/j.efsa.2019.e170910,

title = {Assessment of combined risk to pesticide residues through dietary exposure},

author = {E Chatzidimitriou and A Mienne and S Pierlot and L Noel and X Sarda},

url = {https://efsa.onlinelibrary.wiley.com/doi/abs/10.2903/j.efsa.2019.e170910},

doi = {https://doi.org/10.2903/j.efsa.2019.e170910},

year  = {2019},

date = {2019-01-01},

journal = {EFSA Journal},

volume = {17},

number = {S2},

pages = {e170910},

abstract = {Abstract Plant protection products (PPPs) are preparations intended to protect plants and their products including one or more active substances. The use of PPPs may cause direct or indirect risks. Residues that can remain in or on food might pose a danger to human health through consumption and acute or/and chronic exposure. Authorisation of active substances and PPPs are decided at European and national level, respectively. Risk assessment of dietary exposure to residues of PPPs is regulated by a very extensive legal framework, ensuring consumer safety. The review and evaluation of the residue section of active substance monographs and the dossiers for PPP authorisations within the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) helped gain hands-on experience on food risk assessment, as previewed in the framework of the European Food Risk Assessment Fellowship Programme (EU-FORA). The programme also focused on the cumulative effects of acute exposure to pesticides in food on the human nervous system using probabilistic methodology and it was in continuation of the work carried out by ANSES and the regulated products department residue unit. Using the European Database for processing factors for pesticides in food was one of the main challenges in order to approach a more realistic scenario of exposure. The probabilistic methodology followed was used in accordance with the European Food Safety Authority harmonised guidance.},

keywords = {combined dietary risk assessment, dietary risk assessment, pesticide residues, plant protection products, processing factors},

pubstate = {published},

tppubtype = {article}

}

@article{https://doi.org/10.2903/j.efsa.2018.e16087,

title = {Assessment of occupational and dietary exposure to pesticide residues},

author = {M Markantonis and T Velde-Koerts and C Graven and JD Biesebeek and M Zeilmaker and AG Rietveld and BC Ossendorp},

url = {https://efsa.onlinelibrary.wiley.com/doi/abs/10.2903/j.efsa.2018.e16087},

doi = {https://doi.org/10.2903/j.efsa.2018.e16087},

year  = {2018},

date = {2018-01-01},

journal = {EFSA Journal},

volume = {16},

number = {S1},

pages = {e16087},

abstract = {Abstract Plant protection products (PPPs) are pesticides containing at least one active substance that drives specific actions against pests (diseases). PPPs are regulated in the EU and cannot be placed on the market or used without prior authorisation. EFSA assesses the possible risks of the use of active substances to humans and environment. Member States decide whether or not to approve their use at EU level. Furthermore, Member States decide at national level on the authorisation of PPPs containing approved substances. In agriculture, exposure to PPPs and their residues during occupational tasks is estimated prior to product authorisation, using models fed with study-specific (e.g. absorption, dissipation) and default values. Exposure of workers to pesticide residues reduces with the pesticide's dissipation time during crop-related tasks. However, the current risk assessment gap is that no methodology is available to calculate the re-entry interval (REI) for workers, which specifies how long they should wear personal protective clothing during their first entry into pesticide-sprayed crops. Protective clothing (such as gloves) can reduce pesticide residue exposure to an acceptable level of worker safety. Within the European Food Risk Assessment Fellowship Programme (EU-FORA) assignment, a methodology was developed to calculate agricultural-use-specific and pesticide-specific REIs for which period workers should wear gloves. This was an assignment of the Dutch Ministry of Social Affairs and Employment. Another important aspect of risk assessment to ensure consumer safety is dietary risk assessment. A critical evaluation of residue studies and metabolism of the pesticide in question in crops results in a residue definition for dietary risk assessment and for enforcement and monitoring to define maximum residue limits allowed legally on or in raw agricultural commodities when applying pesticides according to good agricultural practices. This work was assigned by the Dutch Ministry of Health, Welfare and Sport and contributes to the work of the Joint FAO/WHO Meeting on Pesticide Residues.},

keywords = {dermal absorption, dietary risk assessment, maximum residue level, plant protection products, re-entry interval, residue exposure},

pubstate = {published},

tppubtype = {article}

}